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Steroid 21-Hydroxylase

Cytochrome P-450 CYP21 | Steroid 21-Monooxygenase | 21-Hydroxylase | Cytochrome P-450 21-Hydroxylase | Cytochrome P-450(c-21) | Progesterone 21-Hydroxylase | Steroid-21-Hydroxylase | 21 Hydroxylase | Cytochrome P 450 21 Hydroxylase

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

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